I’m interested in how does epigenetic modifications affect transcription. My research focus on how does circadian TF CLOCK:BMAL1 modulates nucleosome removal and TF cooperation to regulate rhythmic gene expression, using single molecule footprinting approach.

Publications:

Nie XY, Menet JS. Circadian regulation of stereotypic chromatin conformations at enhancers. bioRxiv. 2024 Apr 24. (under review at Molecular Cell)

Michael AK, Stoos L, Crosby P, Eggers N, Nie XY., et al. Cooperation between bHLH transcription factors and histones for DNA access. Nature. 2023 Jul 13;619(7969):385-93.

Presentations:

Society for Research on Biological Rhythms (SRBR). Selected for oral presentation 2024, Talk title: “Circadian regulation of chromatin conformations at cis-regulatory elements using single molecule footprinting (SMF)”.

Texas Society for Circadian Biology and Medicine (TSCBM). Oral presentation 2023, Talk title: “Circadian regulation of chromatin conformations at cis-regulatory elements using single molecule footprinting (SMF)”.